A cross plane V8 requires counterweights which means it revs slower and because of the counterweights the crank shaft is 'taller' raising the center of gravity of the engine, also makes it a bigger package, plus the crank weighs more, some say up to 20% more. Tall and revs slow but well balanced. The exhaust pulses are uneven which makes pulse resonance exhaust/tuning more complicated.Flat plane V8's have a second order vibration range, but this is minimized by a racing engines short stroke and light components, its higher in the rev range, and drivers are so highly paid they can stand a little discomfort.
Edited
Reading my post a second time - most of it is what checkered had to say.
