Well, it's possible, but to paraphrase your signature "winning is the art of building cars for races we don't know how will develop, to get results we can barely preview and then, after winning, saying we were expecting it all the time".
BTW, nice signature. Anyway...
For example, dear Moda, let's check the list of teams that have had just one victory during the year.
Let's start witht the 50's and check decade by decade (if I have the time and the wish).
1950: Kurtis Kraft Offenhauser ► Indy 500 ► Probably a car built for that circuit
1951: Idem ► Indy 500 ► Idem
1952: Kuzma Offenhauser ► Indy 500 ► Idem
1953: Kurtis Kraft Offenhauser ► Indy 500 ► Idem
1953: Maserati ► Monza ► Idem
1954: Kurtis Kraft Offenhauser ► Indy 500 ► Idem
1955: Ferrari ► Monaco ► Idem
1955: Kurtis Kraft Offenhauser ► Indy 500 ► Idem
1956: Watson Offenhauser ► Indy 500 ► Idem
1957: Epperly Offenhauser ► Indy 500 ► Idem
1958: Epperly Offenhauser ► Indy 500 ► Idem
1959: Watson Offenhauser ► Indy 500 ► Idem
1959: BRM ► Zandvoort ► This is the exception that confirms the rule!
So, with the exception of BRM, during the 50's ALL the teams that won just one race during the year, did it at tracks for "specialists"
Yeah, I know, there were Indy back then, but, hey, all that I wrote is true.

So, during the 50's the answer to "Base your car design around 1 specific circuit?" is a resounding YES.
I
might continue tomorrow (or if someone wants to do the same for the 60's, I'll continue with the 70's).